EGFR/HER2 Vaccine

A new cancer immunotherapy developed by research team at Yale University is being evaluated in this study led by Therajan LLC

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Kinsey and Tina

Why immunotherapy?

May prevent the recurrence and spreading of cancer
May help when surgery is not possible, or if chemotherapy stops working
May slow or reverse cancer metastasis

How does it work?

Safely activates the immune system against cancer cells that are over-expressing EGFR and HER2 proteins.
The vaccine has already been given to over 600 canine patients. Minimum side effects reported.
May help with many different cancer types. Preliminary data for osteosarcoma and hemangiosarcoma published.
Watch a recent update from the team.

Limitations and Challenges

Today's immunotherapy cannot guarantee every dog will become a long-term survivor.
Researchers are investigating different ways to safely enhance the efficacy and increase the number of responders.

Maggie was diagnosed with osteosarcoma in Jan 2020 and got conventional treatment plus the vaccine. She is still cancer-free.

Ranger's cancer kept on spreading, even after surgery and chemotherapy. But his tumors shrank and disappeared after the EGFR/HER2 vaccine treatment.

Codi's metastatic osteosarcoma began to disappear a month after he received the EGFR/HER2 vaccine injection. He enjoyed 3 extra years as a healthy, happy pup.

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Updates

Feb 3, 2026: Blog Post

Introduction to the EGFR/HER2 Vaccine
Speaker: Prof. Mark Mamula

Dec 16, 2025 | 1 PM PT, 4 PM ET: Zoom Recording

The EGFR/HER2 Canine Cancer Vaccine
Speaker: Prof. Mark Mamula

Apr 25, 2024: Zoom Recording

"How these dogs recovered from lung metastasis."

Oct 28, 2024: Veterinary Cancer Society Meeting

Almost 12-month median survival time was reported for osteosarcoma patients who received palliative radiation plus vaccine WITHOUT amputation.
Longer median survival times (compared to chemotherapy alone) were reported for Stage 1 and Stage 2 hemangiosarcoma canine patients.

They are early results with a small number of patients. More data is being collected.

An Introductory Quick Guide on Canine Cancer Immunotherapy can be downloaded here.