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Can metastasis be stopped?
Find out if your dog qualifies for Tina's Trial:
EGFR/HER2 Vaccine Study
A new cancer immunotherapy developed by researchers at Yale U is being evaluated in this study led by Therajan LLC
NEWS
May 24 2023
Additional eight clinical study sites are beginning to enroll patients with tumors associated with EGFR overexpression. Learn more
Potential benefits of cancer immunotherapy for pups
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May stop or slow recurrence and spreading of cancer
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May help when surgery is not possible, or if chemotherapy doesn't work
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May reverse cancer metastasis
Maggie was diagnosed with osteosarcoma in Jan 2020 and got conventional treatment plus the vaccine. She is still cancer-free.
Ranger's cancer kept on spreading, even after surgery and chemotherapy. But his tumors shrank and disappeared after the EGFR/HER2 vaccine treatment.
Codi's metastatic osteosarcoma began to disappear a month after he received the EGFR/HER2 vaccine injection. He enjoyed 3 extra years as a healthy, happy pup.
How does it work?
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Safely activates the immune system against cancer cells that are over-expressing EGFR and HER2 proteins.
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The vaccine has already been given to over 600 dogs. Minimum side effect reported.
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May help with many different cancer types. Preliminary data for osteosarcoma and hemangiosarcoma published.
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Watch a recent update from the team.
Limitations and challenges
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Today's immunotherapy cannot guarantee every dog will become a long-term survivor.
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Researchers are investigating different ways to safely enhance the efficacy and increase the number of responders.
Learn about strategies that might enhance efficacy of immunotherapy treatments.
Please contact us at info@ccralliance.org
with any questions.
Clinical Study Locations L
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Stay Involved
How can I best help my pup respond to the vaccine?
Anything to avoid? Can dietary intervention help?
What's the relationship between cancer and gut microbiome?
Will checkpoint inhibitors become available?
How can I contribute my pup's samples to the study?
Receive email updates and invitation to future zoom sessions.
Please contact us at info@ccralliance.org
with any questions.
Updates and Resources
Updates
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May 25, 2023 Many of the new clinics are creating wait lists. Additional vaccine are being shipped to all the clinics.
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May 20, 2023 USDA approves eight additional clinical trial sites, making the total 10 study locations.
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May 17, 2023 New locations will soon be announced. Please sign up if you'd like to receive an email notification of new study locations and other information about immunotherapy and research.
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May 17, 2023 Washington State University WSU will be pausing radiation treatment from end of June until Sept as they update their linear accelerator. If you live in the Pacific Northwest and are looking for vaccine + radiation therapy option, please consult your oncologist. The veterinary hospital in Portland, Oregon is offering radiation therapy. None of the clinics in Seattle offers radiation therapy.
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May 3, 2023 Bridge Animal Referral Center BARC in Edmonds WA is continuing to enroll patients. Call for appointment. (It’s easiest and quickest to make an appointment if your dog is already seeing an oncologist because your dog just needs to come in for office visits for two vaccine shots plus a blood draw. If you need to set up an appointment as a new oncology patient, the wait time may be 2-3 months. By the way, there is no radiation treatment option at this clinic)
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May 3, 2023 Washington State University Veterinary Hospital is accepting patients. For dogs who are not candidate for surgery. Radiation therapy + vaccine.
Other Resources
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Yale's EGFR/HER2 Vaccine Helps Dogs With Metastasis?! (9min read) An Introduction
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EGFR/HER2 Vaccine Clinical Study Status: Tina’s Trial Video ( 25 min )
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EGFR/HER2 Vaccine Q&A Video (24 min)
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Other vaccines and immunotherapy for Osteosarcoma (2 min read) List of other immunotherapy studies and treatments with for dogs with osteosarcoma that are broadly available in the US or vet school studies.
Papers and Presentations
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2021 Publication: Vaccine-induced ErbB (EGFR/HER2)-specific immunity in spontaneous canine cancer
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2022 Presentation Veterinary Cancer Society Annual Meeting
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2023 Presentation Veterinary Cancer Society Mid-Year Meeting
(email info@ccralliance.org if you’d like a copy of presentations)